THE EFFECT of THE ETHANOL EXTRACT of SURUHAN (Peperomia pelucida (L.) HBK) HERBAL to BLOOD GLUCOSE and C-reactive Protein LEVELS in STREPTOZOTOCIN-INDUCED DIABETIC RATS

Sri Hartati H.1, R.P. Andri Putranto1, Hari Purnomo S.1
1Sebelas Maret University School of Medicine, Solo


Objective: This study was aimed to evaluate the effect of ethanol extract of Peperomia pelucida (L.) HBK herbal to blood glucose and C-reactive Protein (CRP) levels in streptozotocin-induced diabetic rats.
Methods: Diabetes was induced by a single intraperitoneal (i.p) injection of streptozotocin (65 mg/kg body weight) freshly dissolved in 0.02 M citrate saline buffer. Only rats with blood glucose levels ≥200 mg/dL were included. Animals were sacrificed after 2 weeks of diabetes. The diabetes was confirmed by measuring the level of blood glucose, using a Blood Glucose Test Meter (Gluco Drï index penelitian dosen